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Alexander Weng Selected Research

Immunotoxins (Immunotoxin)

11/2017Targeted dianthin is a powerful toxin to treat pancreatic carcinoma when applied in combination with the glycosylated triterpene SO1861.
9/2017Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma.
3/2017Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies.
12/2016Saponins from Saponaria officinalis L. Augment the Efficacy of a Rituximab-Immunotoxin.
1/2016Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers.
10/2015Combinatorial approach to increase efficacy of Cetuximab, Panitumumab and Trastuzumab by dianthin conjugation and co-application of SO1861.
2/2015Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent.
11/2014Dianthin-EGF is an effective tumor targeted toxin in combination with saponins in a xenograft model for colon carcinoma.
4/2014High-speed countercurrent chromatographic recovery and off-line electrospray ionization mass spectrometry profiling of bisdesmodic saponins from Saponaria officinalis possessing synergistic toxicity enhancing properties on targeted antitumor toxins.
1/2014Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy.
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Alexander Weng Research Topics

Disease

28Neoplasms (Cancer)
03/2022 - 09/2009
3Neuroblastoma
03/2022 - 10/2018
2Glioblastoma (Glioblastoma Multiforme)
01/2019 - 09/2017
2Carcinoma (Carcinomatosis)
11/2014 - 09/2010
1Pancreatic Neoplasms (Pancreatic Cancer)
11/2017
1Glioma (Gliomas)
09/2017
1Cystic Fibrosis (Mucoviscidosis)
01/2017
1B-Cell Lymphoma (Lymphoma, B Cell)
12/2016
1Lymphoma (Lymphomas)
02/2015
1Leukemia
02/2015
1Colonic Neoplasms (Colon Cancer)
11/2014
1Hemolysis
04/2013
1Uterine Cervical Neoplasms (Cancer of the Cervix)
09/2010
1Atherosclerosis
01/2004

Drug/Important Bio-Agent (IBA)

18Immunotoxins (Immunotoxin)IBA
11/2017 - 09/2009
14SaponinsIBA
10/2018 - 10/2009
7Epidermal Growth Factor (EGF)IBA
11/2014 - 10/2009
6Proteins (Proteins, Gene)FDA Link
11/2017 - 06/2012
5SaporinsIBA
04/2019 - 03/2010
5TriterpenesIBA
11/2017 - 10/2013
4ErbB Receptors (EGF Receptor)IBA
11/2014 - 09/2009
3LigandsIBA
01/2018 - 06/2012
3AntibodiesIBA
09/2017 - 11/2013
2Ribosome Inactivating ProteinsIBA
01/2022 - 01/2014
2DNA (Deoxyribonucleic Acid)IBA
08/2021 - 10/2018
2SO1861IBA
11/2017 - 09/2017
2GlycosidesIBA
09/2017 - 05/2012
2AntigensIBA
06/2012 - 01/2004
1Pharmaceutical PreparationsIBA
08/2021
1Factor IX (Coagulation Factor IX)FDA LinkGeneric
08/2021
1AdenineFDA LinkGeneric
01/2019
13-O-(sulfo)lup-20(29)-en-23,28-dioic acidIBA
01/2019
1Complex MixturesIBA
10/2018
1LuciferasesIBA
10/2018
1Glycoside Hydrolases (Endoglycosidases)IBA
01/2018
1monomethyl auristatin EIBA
09/2017
1Calcitonin Receptors (Calcitonin Receptor)IBA
09/2017
1Immunoconjugates (Immunoconjugate)IBA
09/2017
1Gelonium multiflorum GEL proteinIBA
09/2017
1Small Interfering RNA (siRNA)IBA
01/2017
1Rituximab (Mabthera)FDA Link
12/2016
1Monoclonal AntibodiesIBA
11/2013
1EnzymesIBA
06/2012
1Therapeutic UsesIBA
10/2009
1theasinensin AIBA
09/2009
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
01/2004

Therapy/Procedure

17Therapeutics
03/2022 - 09/2009